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From photon to mitochondrion

One enzyme explains almost all of the rest.

Red light therapy is not heat, not UV, and not magic. It is a specific photochemical reaction, in a specific organelle, at specific wavelengths. Here is the full chain — and where it stops.

600–950 nm, the optical window where human tissue lets light through
0 UV no ultraviolet wavelength anywhere in the spectrum used
5–6 J per spot, the dose that emerges from muscle meta-analyses
10–20 minutes per area, the duration protocols converge on

In short

Red light therapy is neither heat nor ultraviolet. Between 600 and 950 nm, light passes through living tissue and a mitochondrial enzyme — cytochrome c oxidase — absorbs it. Everything else follows from that. Dose matters more than power, and consistency matters more than either.

  • The usable window runs from 600 to 950 nm. Below it, haemoglobin absorbs everything; above it, water takes over. That is not a commercial choice, it is a physical constraint.
  • The identified photoacceptor is cytochrome c oxidase, the last link of the respiratory chain inside the mitochondrion.
  • No ultraviolet in the spectrum used: it starts at 590 nm, and UV stops at 400 nm. No tanning, and no UV-related photocarcinogenic risk.
  • The dose response is biphasic: too little energy does nothing, too much reduces the effect instead of amplifying it. Stronger is not better.
  • Protocols converge on 10 to 20 minutes per area, 3 to 5 times a week, sustained over weeks. Skin and hair trials measure at sixteen weeks.
  • The most decisive variable is not on the spec sheet: it is consistency. A device you do not use has an efficacy of zero, whatever its nanometres.

Page reviewed on 09/09/2026. Antared devices are wellness products: they do not diagnose, treat or cure any disease.

The mechanism

Four steps, and nothing to take on faith.

This chain is the one described in the reference review from Harvard's Wellman Center for Photomedicine. It remains a leading hypothesis, not a dogma.

See the sources

The photon crosses the skin

Between 600 and 950 nm, haemoglobin and water absorb little: this is the optical window of living tissue. Below it, blood absorbs everything; above it, water takes over. The window is not a marketing choice, it is a physical constraint.

Cytochrome c oxidase absorbs it

This enzyme is the last link of the respiratory chain, inside the mitochondrion. Its copper and haem centres absorb precisely in the red and near-infrared. It is the photoacceptor identified by Tiina Karu.

Nitric oxide lets go

Under stress, nitric oxide binds to the enzyme and slows electron transport. The leading hypothesis is that the photon displaces that molecule. Once released, it also dilates blood vessels — hence the flush during a session.

ATP rises, the cell signals

Electron transport resumes, ATP production rises, and signalling cascades switch on: protein synthesis, cell migration, anti-inflammatory response. It is at this level, and not before, that the effects observed in clinical trials become plausible.

The wavelengths

Seven spectra, seven different jobs.

A nanometre decides how deep the light reaches and which molecule absorbs it. The full spectrum, relative depths and the device-by-device mapping have their own page.

See the wavelengths

Dose

Longer and stronger is not better. That has been measured.

Photobiomodulation follows a biphasic dose response: the effect rises with dose, plateaus, then falls back. It is the point this industry's marketing avoids most carefully.

Why we write it down

Duration

Protocols converge around 10 to 20 minutes per area. Doubling the session does not double the result, and may reduce it.

Frequency

Three to five sessions a week, sustained over weeks. Skin and hair trials measure at sixteen weeks, not seven days.

Distance

For a panel, between 15 and 50 cm depending on the device's irradiance. A worn device — mask, knee wrap, boot — removes this variable entirely.

Consistency

The most decisive variable, and the only one entirely up to you. A device you do not use has an efficacy of zero, whatever its nanometres.

What this mechanism does not prove

  • A plausible chain is not a clinical result. That light is absorbed by an enzyme implies no felt benefit. Trials are what measure that, and they live on the Science page.
  • Cytochrome c oxidase remains the leading hypothesis, not a settled fact. Other candidate photoacceptors are discussed in the literature, and their respective share is not resolved.
  • Trial doses do not transfer as they are. A hospital laser protocol on a delimited area does not convert mechanically into minutes in front of an LED panel at home. The figures on this page are orders of magnitude.
  • No effect on any disease is promised here, on this page or anywhere on this site. Our devices are wellness products. If you have symptoms, an ongoing treatment or are pregnant, a healthcare professional's advice takes precedence.

Safety and dose

What to know before your first session.

Is there any UV in red light therapy?

No. The spectrum used starts at 590 nm, well above ultraviolet, which stops at 400 nm. There is no tanning and no UV-related photocarcinogenic risk. Any warmth you feel during a session comes from the LEDs themselves, not from far-infrared heating.

How long should a red light therapy session last?

Protocols converge on 10 to 20 minutes per area, 3 to 5 times a week. Doubling the duration does not double the result and may reduce it, because the dose response is biphasic. Three short sessions you keep every week beat one long session every fortnight.

Do I need eye protection during a session?

Do not stare into the LEDs. The light is not dangerous at home irradiances, but it is dazzling in visible red and invisible in the near-infrared: the blink reflex does not protect you. Close your eyes, or use the goggles supplied with the device.

Who should ask a doctor before using a device?

Anyone pregnant, on photosensitising medication (some antibiotics, retinoids, St John's wort), with an undiagnosed skin lesion, an eye condition, photosensitive epilepsy — avoid pulsed modes in that case — or undergoing cancer treatment. Our devices are wellness products: they replace no medical advice.

How long before anything shows?

It depends what you are measuring. For muscle recovery, trials see an effect from the first session. For skin and hair, the reference studies measure at sixteen weeks of regular sessions. Be sceptical of any brand promising a visible result in a week.

Is a more powerful device better?

Not beyond a certain point. The biphasic response means that past the optimal dose the effect declines. High irradiance mainly shortens the session: it does not replace consistency, and it makes respecting durations more important, not less.

How far should I sit from a panel?

Between 15 and 50 cm depending on the irradiance the manufacturer states, and that irradiance must be given at a stated distance. A worn device — mask, cap — removes the variable altogether, which is the main reason to choose that format.

How do I compare two devices honestly?

Look at three numbers, and only three: irradiance in mW/cm² at a stated distance, the exact wavelengths in nanometres, and the area actually lit. An LED count on its own tells you nothing. Our parameters are on every product page, and our selection method on our values.

Questions about the trial, warranty and certification are gathered on the general FAQ. To apply these figures to a specific moment of your week, the protocols give seven sessions with numbers, and the benefits page lists what has been measured, domain by domain.